Swine flu: Having very recently mutated to allow human/human transmission, it has already spread around the globe, leading to fears of a global pandemic.  To be fair, I think the mainstream news media have been doing more to fan the flames of fear (while sanctimoniously denying any intent to do so) than the flu itself.  As of this evening early Tuesday morning, only 40 50 cases had been reported inside the United States, and not a single fatality. CDC laboratory tests thus far indicates that the infection responds well to antiviral drugs such as oseltamivir (Tamiflu) and zanamivir (Relenza), which are being stockpiled in a number of states.  Maryland has already opened a swine flu command center right in my home city of Baltimore, in anticipation of likely infections occurring in the Baltimore-Washington metropolitan area.  CDC lab tests have also indicated that the other two FDA-approved antiviral drugs for flu, amantadine (Symmetrel) and rimantadine (Flumadine), are ineffective against the swine flu.  Both oseltamivir and zanamivir are neuraminidase inhibitors, which work by blocking the action of the viral neuraminidase protein.  This is the protein on the surface of influenza viruses that allows it to be released from the host cell in the process known as “budding.”  Amantadine and rimantadine are both M2 protein inhibitors, drugs whose mechanism of action involves blocking the ion channel that removes a virion’s coating and releases its genetic content into the cytoplasm of the host cell.  It is worth noting that poultry farmers in China used amantadine to guard againt the H5N1 avian flu in chickens, an ill-advised practice (H. sapiens as an agent of natural selection!) that has led to the abundance of influenza strains resistant to amantadine.

It’s too early yet to tell whether the swine-flu fatalities in Mexico will be seen here in the United States or elsewhere around the world, but we probably won’t have to wait very long to find out.  As the eccentric chaotician Ian Malcolm said in Jurassic Park, “life finds a way” – we had better work hard to ensure that it’s human life that finds a way this time.  If you’re wondering what you can do, look at this guide on the US Department of Health and Human Services’ PandemicFlu.gov website.  And, of course, you can follow the CDC’s swine flu updates on Twitter.

In that vein, I lastly want to commend President Barack Obama, who, speaking today before the National Academy of Sciences, made a remarkable (and badly needed) commitment to the advancement of American science. After describing how the current swine flu emergency should remind us of the necessity of science, and among many breaks for applause, Obama said:

I believe it is not in our character, the American character, to follow.  It’s our character to lead.  And it is time for us to lead once again.  So I’m here today to set this goal:  We will devote more than 3 percent of our GDP to research and development.  We will not just meet, but we will exceed the level achieved at the height of the space race, through policies that invest in basic and applied research, create new incentives for private innovation, promote breakthroughs in energy and medicine, and improve education in math and science.

That’s why I campaigned for this guy. Let’s all make sure we hold him to this promise.